The medicalization of transhumanist technologies demands our prompt and undivided attention. This article surveys the principal body/mind enhancement goals of transhumanist medicine and the means it would employ-genetic, robo, info-, and nanotechnologies-to accomplish those ends (Part One). Second, it engages Christian anthropological and natural law principles to evaluate the populist and essentialist concerns these therapeutic/enhancement interventions provoke (Part Two). And, third, it proposes formation of a Catholic medical think tank to appraise whether transhumanist biotechnologies can serve human dignity and, to the extent they can, to formulate wise clinical/administrative guidelines for their inclusion in US Catholic healthcare settings (Part Three). NONTECHNICAL SUMMARY: This article explores the body/mind enhancement goals of transhumanist medicine, evaluates the biotechnological means to accomplish those therapeutic/enhancement goals, and suggests the formation of a Catholic medical think tank to formulate wise clinical/administrative guidelines for the inclusion of genetic, robo, info-, and nanotechnologies in US Catholic healthcare settings.