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Analytic methods for assessing the results of infertility therapy are reviewed and deficiencies discussed. A classification and staging scheme to define the type and severity of infertility problems is needed. Once homogeneous groups of patients are defined, the results of infertility therapy can be documented by the life-table method of analysis. A detailed description and format for this type of analysis are presented. To help conceptualize statistical probability as it pertains to infertility data, we have borrowed a mathematical model of fertility from demographers. This model can be used to predict the cumulative probability of conception over time, given a certain monthly probability of conception or fecundability. Also given that a couple has a certain duration of infertility, the model can be used to provide an estimate of an upper limit of the couple's likely monthly fecundability.

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Statistical methods in evaluating the outcome of infertility therapy**Supported in part by National Cancer Institute, National Institutes of Health Trainee Grant 2T32 CA 09001-04 (Department of Epidemiology, Harvard University School of Public Health)

Cramer DW et al., 1979

Cramer DW, Walker AM, Schiff I

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