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The luteal phase plasma progesterone levels of 341 control patients were compared with those in 25 patients with early and 12 patients with advanced breast cancer. There was a significant increase of ovulatory failure and luteal deficiency in patients with advanced breast cancer.

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Ovulatory failure in a normal population and in patients with breast cancer.

Swain MC et al., 1974

Swain MC, Bulbrook RD, Hayward JL

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