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OBJECTIVES: To assess the effects of oral estriol on the bone mineral density (BMD) and bone metabolism in postmenopausal women.
METHODS: Seventy-five natural postmenopausal women with a BMD of more than 10% below the peak bone density were treated for 50 weeks with 2 mg/day estriol (E3) cyclically and 0.8 g/day of calcium lactate continuously. BMDs at L2-L4 were measured by dual energy X-ray absorptiometry (DXA).
RESULTS: The BMD increased 1.79% (p < 0.01 vs. pretreatment) after 50 weeks, accompanied with decrease of biochemical markers of bone turnover. With regard to climacteric symptoms, Kupperman's menopausal index improved (p
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Effect of estriol on bone loss in postmenopausal Japanese women: a multicenter prospective open study.
Minaguchi H et al., 1996
Minaguchi H, Uemura T, Shirasu K, Sato A, Tsukikawa S, Ibuki Y, Mizunuma H, Aso T, Koyama T, Nozawa S, Ohta H, Ikeda T, Kusuhara K, Ochiai K, Kato J, Kinoshita T, Tanaka K, Minagawa Y, Kurabayashi T, Fukunaga M
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