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What fertility supplements have evidence behind them (CoQ10, vitamin D, DHEA, inositol)?

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RRM uses targeted nutritional testing to identify specific deficiencies before recommending supplements, focusing on CoQ10, vitamin D, folate, and omega-3 fatty acids based on individual metabolic needs and documented evidence.

RRM's Evidence-Based Supplement Protocol

Restorative Reproductive Medicine evaluates nutritional status through comprehensive testing before any supplement recommendations. We measure vitamin D levels, assess MTHFR gene variants for folate metabolism, and evaluate antioxidant markers. This targeted approach ensures couples address actual nutritional barriers to conception rather than following generic protocols.

CoQ10 and its active form ubiquinol show measurable benefits for both egg and sperm quality. RRM recommends ubiquinol for couples over 35 or those with documented mitochondrial dysfunction. Vitamin D deficiency affects 67-85% of women with PCOS and correlates with endometriosis severity. We test and correct deficiencies to optimal ranges, not just "normal" laboratory values.

For couples with MTHFR variants, RRM uses methylated folate forms rather than synthetic folic acid. Omega-3 fatty acids support healthy inflammation responses and hormone production. The key principle: supplements support the body's natural reproductive processes when specific deficiencies exist, but they cannot replace proper diagnosis and treatment of underlying conditions.

  • CoQ10 supplementation improved oocyte quality markers in women over 35 and enhanced sperm concentration and motility (Bentov et al., 2014; Safarinejad, 2012)
  • Vitamin D deficiency found in 67-85% of women with PCOS, with correction improving ovulation rates (Thomson et al., 2012)
  • Myo-inositol restored ovulation in 70% of women with PCOS within 16 weeks (Costantino et al., 2009)
  • Omega-3 supplementation improved sperm quality parameters in multiple studies (Safarinejad et al., 2010)

RRM's supplement protocols target documented deficiencies through testing, using evidence-based nutrients to support natural reproductive function while addressing root causes of fertility challenges.

This information is educational and not a substitute for individualized medical care. Consult your RRM clinician or healthcare provider for guidance specific to your situation.

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