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Is RRM evidence‑based? (key trials, registries, and guidelines)

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RRM is evidence-based through peer-reviewed outcome studies including Stanford 2008, Stanford BMC 2021, and the International NPT Evaluation 2022, plus ongoing data collection through the STORRM registry.

Published Outcome Data

The evidence base for Restorative Reproductive Medicine spans over 15 years of peer-reviewed publications. The foundational Stanford 2008 study established initial pregnancy rates for couples using NaProTechnology protocols. This was followed by the larger Stanford BMC 2021 analysis, which documented outcomes across multiple RRM centers. The International NPT Evaluation published in HROpen 2022 provided the most comprehensive data to date on RRM effectiveness across different conditions.

Beyond individual studies, the STORRM registry (Systematic Tracking of Outcomes in Restorative Reproductive Medicine) continuously collects real-world data from RRM practices. This registry approach allows for ongoing evaluation of protocols and refinement of treatment approaches based on measurable outcomes.

Clinical Guidelines Integration

RRM clinicians follow established medical guidelines for conditions like PCOS, recurrent pregnancy loss, and endometriosis. The difference lies in the approach. Where conventional guidelines often recommend suppressive medications or immediate ART, RRM protocols first address underlying pathophysiology. For example, PCOS guidelines recommend metformin and lifestyle modifications. RRM expands this to include comprehensive hormonal assessment, cycle tracking, and targeted nutritional protocols.

  • Stanford 2008: Initial pregnancy rate documentation for NaProTechnology protocols
  • Stanford BMC 2021: Multi-center outcome analysis across RRM practices
  • International NPT Evaluation (HROpen 2022): Comprehensive effectiveness data across conditions
  • STORRM registry: Ongoing real-world data collection and protocol refinement
  • Integration with PCOS, RPL, and endometriosis clinical guidelines

The RRM Evidence Approach

RRM evidence collection emphasizes long-term reproductive health outcomes rather than single-cycle success rates. This includes tracking live birth rates, pregnancy loss reduction, and cycle health improvement over time. The focus on cause-based treatment means measuring not just conception, but resolution of underlying conditions like luteal phase defects, ovulatory dysfunction, and inflammatory processes.

RRM protocols undergo continuous refinement based on patient outcomes documented in the STORRM registry. This allows for real-time protocol adjustments based on what works best for specific patient populations and conditions.

RRM combines peer-reviewed outcome studies with continuous registry data collection and established clinical guidelines to provide evidence-based reproductive care focused on addressing root causes rather than bypassing them.

This information is educational and not a substitute for individualized medical care. Consult your RRM clinician or healthcare provider for guidance specific to your situation.

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